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DIRECT-SAFE2022
Direct EVT did not meet NI vs bridging therapy across AU/NZ/China/Vietnam.
EXTEND2019
Alteplase 4.5–9 h with perfusion-selected imaging improves recovery.
COMPASS2019
Aspiration-first was noninferior to stent-retriever-first for 90-day mRS 0–2.
THEIA2025
First phase 3 RCT of IV alteplase vs aspirin for CRAO within 4.5h; directional but underpowered; safety reassuring.
PICSS2002
Non-prespecified subgroup of a substudy; low-intensity warfarin did not beat aspirin.