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NOR-TEST 2 (Part A)2022
Tenecteplase 0.4 mg/kg in moderate-severe stroke caused 6× more sICH and 3× more deaths vs alteplase.
SOCRATES2016
Ticagrelor monotherapy did not beat aspirin for stroke/MI/death after minor stroke/TIA (P=0.07).
RESPECT (Original 2013)2013
Original 2013 RESPECT primary publication; ITT primary NOT met at median 2.1y (HR 0.49, P=0.08 borderline). The 2017 extended follow-up later converted the result.
HAMLET2009
Hemicraniectomy up to 96 h cuts mortality 38 pp in malignant MCA infarction; no mRS ≤3 benefit.
ECASS III2008
Alteplase benefit extends from 3 h to 4.5 h after onset.