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DIRECT-MT2020
Direct EVT met noninferiority vs bridging in Chinese centers; CI margin narrow.
AcT2022
Tenecteplase 0.25 mg/kg non-inferior to alteplase in routine IVT within 4.5 h.
OPTIMAS2024
Early DOAC (≤4 d) noninferior to delayed start after AF-related stroke in the largest trial to date.
ENRICH2024
Minimally invasive parafascicular surgery for lobar ICH 30–80 mL improves utility-weighted mRS at 180 d.
SPS32012
Long-term DAPT (clopidogrel+aspirin) in lacunar stroke increases mortality and bleeding with no stroke reduction.