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SPS32012
Long-term DAPT (clopidogrel+aspirin) in lacunar stroke increases mortality and bleeding with no stroke reduction.
RESPECT (Original 2013)2013
Original 2013 RESPECT primary publication; ITT primary NOT met at median 2.1y (HR 0.49, P=0.08 borderline). The 2017 extended follow-up later converted the result.
ESCAPE-MeVO2025
Routine EVT for medium-vessel occlusion shows no functional benefit and higher sICH (5.4% vs 2.2%).
DAWN2018
Thrombectomy to 24 h with clinical–core mismatch: 49% vs 13% independence, NNT 2.8.
SAMMPRIS2011
Wingspan stenting as initial therapy for symptomatic ICAS 70–99% causes harm vs aggressive medical therapy.