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ARAMIS2023
DAPT non-inferior to alteplase for minor nondisabling stroke at 90 d (93.8% vs 91.4%).
ECASS III2008
Alteplase benefit extends from 3 h to 4.5 h after onset.
CLOSE2017
In cryptogenic stroke <60 with PFO + ASA or large shunt, PFO closure abolished recurrent stroke vs antiplatelet alone.
HAMLET2009
Hemicraniectomy up to 96 h cuts mortality 38 pp in malignant MCA infarction; no mRS ≤3 benefit.
RIGHT-22019
Ultra-acute transdermal GTN for presumed stroke shows no benefit and a harm signal in ICH.